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2016年12月最新進(jìn)展

發(fā)布時間:2017-03-17 瀏覽數(shù):14764次

1、Codexis向Tate&Lyle出售新的食品用酶

2016年12月6日:Codexis宣布與Tate&Lyle簽訂了一份關(guān)于提供食品原料生產(chǎn)專用酶的獨家協(xié)議。

2、Amyris向Nikkol集團(tuán)出售50%的股份

2016年12月13日,Amyris公司宣布與Nikkol集團(tuán)成立化妝品合資公司。Amyris以2000萬美元的

價格向Nikkol集團(tuán)出售其子公司Neassance50%的股權(quán),成立該合資公司。

3、Evolva獲得生產(chǎn)甜菊糖的關(guān)鍵專利

2016年12月19日,瑞士一家生物化學(xué)公司Evolva宣布獲得美國專利申請的準(zhǔn)許通知書,并稱該

技術(shù)為“最經(jīng)濟(jì)有效的制造甜菊糖苷的生產(chǎn)方法”。


會議預(yù)告

1)2017年3月6日-8日,有機(jī)過程的研究和開發(fā),帕薩迪納,美國;

https://scientificupdate.co.uk/index.php/conferences/conferences-and-

workshops/details/297-Organic-Process-Research-and-Development-Europe.html

2)2017年5月16日-18日Informex貿(mào)易展覽和會議,賓夕法尼亞州費城,美國;

http://www.informex.com/

3)2017年7月9日-13日,Biotrans 2017,匈牙利布達(dá)佩斯;

http://www.biotrans2017.co



最新發(fā)表文獻(xiàn)摘選:

Enzymes beat chemists in the formation of unnatural bonds.

Ducharme J, Auclair K. Chembiochem. 2016 Dec 27. doi: 10.1002/cbic.201600692. [Epub

ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28026102


Inversion of substrate stereoselectivity of horse liver alcohol

dehydrogenase by substitutions of Ser-48 and Phe-93.

Kim K, Plapp BV. Chem Biol Interact. 2016 Dec 23. pii: S0009-2797(16)30754-2. doi:

10.1016/j.cbi.2016.12.016. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28025168


Alkaline serine proteases from Helicoverpa armigera: potential

candidates for industrial applications.

Akbar SM, Sharma HC. Arch Insect Biochem Physiol. 2016 Dec 26. doi:

10.1002/arch.21367. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28019702


Highly efficient bioreduction of 2-hydroxyacetophenone to (S)- and (R)-1-

phenyl-1, 2-ethanediol by two substrate tolerance carbonyl reductases

with cofactor regeneration.

Cui ZM, Zhang JD, Fan XJ, Zheng GW, Chang HH, Wei WL. J Biotechnol. 2016 Dec 20. pii:

S0168-1656(16)31663-7. doi: 10.1016/j.jbiotec.2016.12.016. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28011130


The catalytic domain of Penicillium crustosum endoglucanase EGL1 has

cellulose-binding capacity and cellulolytic activity.

Xiong W, Yang JK, Chen FY, Han ZG. Enzyme Microb Technol. 2017 Feb;97:71-81. doi:

10.1016/j.enzmictec.2016.11.007.

https://www.ncbi.nlm.nih.gov/pubmed/28010775


Highly regioselective hydroxylation of polydatin, a resveratrol

glucoside, for one-step synthesis of astringin, a piceatannol glucoside,

by P450 BM3.

Le TK, Jang HH, Nguyen HT, Doan TT, Lee GY, Park KD, Ahn T, Joung YH, Kang HS, Yun

CH. Enzyme Microb Technol. 2017 Feb;97:34-42. doi: 10.1016/j.enzmictec.2016.11.003.

https://www.ncbi.nlm.nih.gov/pubmed/28010771


Evolutionary drivers of thermoadaptation in enzyme catalysis.

Nguyen V, Wilson C, Hoemberger M, Stiller JB, Agafonov RV, Kutter S, English J,

Theobald DL, Kern D. Science. 2016 Dec 22. pii: aah3717. doi:

10.1126/science.aah3717. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28008087


Designing selectivity in dirhodium metallopeptide catalysts for protein

modification.

Martin SC, Vohidov F, Wang H, Knudsen S, Marzec AA, Ball ZT. Bioconjug Chem. 2016 Dec

30. doi: 10.1021/acs.bioconjchem.6b00716. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28035818


Structure-guided reprogramming of a hydroxylase to halogenate its small

molecule substrate.

Mitchell AJ, Dunham NP, Bergman JA, Wang B, Zhu Q, Chang WC, Liu X, Boal AK.

Biochemistry. 2016 Dec 28. doi: 10.1021/acs.biochem.6b01173. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28029241


Directed evolution of P450cin for mediated electron transfer.

Belsare KD, Horn T, Ruff AJ, Martinez R, Magnusson A, Holtmann D, Schrader J,

Schwaneberg U. Protein Eng Des Sel. 2016 Dec 22. doi: 10.1093/protein/gzw072. [Epub

ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28007937


Chemoenzymatic Dynamic Kinetic Resolution of Secondary Alcohols using an

Air and Moisture stable Iron Racemization Catalyst.

B?ckvall JE, Gustafson KG, Guemundsson A, Lewis K. Chemistry. 2016 Dec 22. doi:

10.1002/chem.201605754. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28005307


Intracellular Microreactors as Artificial Organelles to Conduct Multiple

Enzymatic Reactions Simultaneously.

Godoy-Gallardo M, Labay C, Jansman MM, Ek PK, Hosta-Rigau L. Adv Healthc Mater. 2016

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https://www.ncbi.nlm.nih.gov/pubmed/28004530


Gene cloning, recombinant expression, purification and characterization

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Hayashi M, Okada A, Yamamoto K, Okugochi T, Kusaka C, Kudou D, Nemoto M, Inagaki J,

Hirose Y, Okajima T, Tamura T, Soda K, Inagaki K. J Biochem. 2016 Dec 21. pii:

mvw083. doi: 10.1093/jb/mvw083. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/28003434


A Single Amino Acid Mutation Converts (R)-5-Diphosphomevalonate

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Motoyama K, Unno H, Hattori A, Takaoka T, Ishikita H, Kawaide H, Yoshimura T, Hemmi

H. J Biol Chem. 2016 Dec 21. pii: jbc.M116.752535. doi: 10.1074/jbc.M116.752535.

[Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28003359

Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene

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Vasta JD, Choudhary A, Jensen KH, McGrath NA, Raines RT. Biochemistry. 2016 Dec 21.

doi: 10.1021/acs.biochem.6b00976. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28001367


Semi-Rational Engineering of Leucine Dehydrogenase for L-2-Aminobutyric

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Xu JM, Cheng F, Fu FT, Hu HF, Zheng YG. Appl Biochem Biotechnol. 2016 Dec 20. doi:

10.1007/s12010-016-2369-0. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28000046


Production of 8,11-Dihydroxy and 8-Hydroxy Unsaturated Fatty Acids from

Unsaturated Fatty Acids by Recombinant Escherichia coli Expressing 8,11-

Linoleate Diol Synthase from Penicillium chrysogenum.

Kim MJ, Seo MJ, Shin KC, Oh DK. Biotechnol Prog. 2016 Dec 20. doi: 10.1002/btpr.2426.

[Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27997074


Peroxygenases en route to becoming dream catalysts. What are the

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Wang Y, Lan D, Durrani R, Hollmann F. Curr Opin Chem Biol. 2016 Dec 16;37:1-9. doi:

10.1016/j.cbpa.2016.10.007. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/27992798


Enantiocomplementary Synthesis of ?-Nitroketones Using Designed and

Evolved Carboligases.

Garrabou X, Verez R, Hilvert D. J Am Chem Soc. 2016 Dec 22. doi:

10.1021/jacs.6b11928. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27992715


Broad substrate affinity and catalytic diversity of fibrinolytic enzyme

from Pheretima posthumous-Purification and molecular characterization

study.

Verma MK, Pulicherla KK. Int J Biol Macromol. 2017 Feb;95:1011-1021. doi:

10.1016/j.ijbiomac.2016.10.090.

https://www.ncbi.nlm.nih.gov/pubmed/27984142


Laccase Activity in CTAB-Based Water-in-Oil Microemulsions.

Azimi M, Nafissi-Varcheh N, Faramarzi MA, Aboofazeli R. Iran J Pharm Res. 2016

Summer;15(3):441-452.

https://www.ncbi.nlm.nih.gov/pubmed/27980579


Green synthesis of β-sitostanol esters catalyzed by the versatile

lipase/sterol esterase from Ophiostoma piceae.

Molina-Gutiérrez M, Hakalin NL, Rodríguez-Sanchez L, Prieto A, Martínez MJ. Food

Chem. 2017 Apr 15;221:1458-1465. doi: 10.1016/j.foodchem.2016.11.005.

https://www.ncbi.nlm.nih.gov/pubmed/27979115


Chemical biology: A radical change in enzyme catalysis.

Bornscheuer UT. Nature. 2016 Dec 14;540(7633):345-346. doi: 10.1038/540345a. No

abstract available.

https://www.ncbi.nlm.nih.gov/pubmed/27974776


Accessing non-natural reactivity by irradiating nicotinamide-dependent

enzymes with light.

Emmanuel MA, Greenberg NR, Oblinsky DG, Hyster TK. Nature. 2016 Dec 14;540(7633):414-

417. doi: 10.1038/nature20569.

https://www.ncbi.nlm.nih.gov/pubmed/27974767


Functional Characterization of a Novel Amidase Involved in

Biotransformation of Triclocarban and its Dehalogenated Congeners in

Ochrobactrum sp. TCC-2.

Yun H, Liang B, Qiu J, Zhang L, Zhao Y, Jiang J, Wang A. Environ Sci Technol. 2017

Jan 3;51(1):291-300. doi: 10.1021/acs.est.6b04885.

https://www.ncbi.nlm.nih.gov/pubmed/27966913


Eichhornia crassipes: Agro-waster for a novel thermostable laccase

production by Pycnoporus sanguineus SYBC-L1.

Wang Z, Liu J, Ning Y, Liao X, Jia Y. J Biosci Bioeng. 2016 Dec 7. pii: S1389-1723(16)

30287-0. doi: 10.1016/j.jbiosc.2016.09.005. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27964864


Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin

Biosynthesis.

Fiers WD, Dodge GJ, Sherman DH, Smith JL, Aldrich CC. J Am Chem Soc. 2016 Dec 14;138

(49):16024-16036. https://www.ncbi.nlm.nih.gov/pubmed/27960309

 

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